Treatment of depression with venlafaxine is associated with increased levels of C-terminal cross-linked telopeptide (CTX) of type 1 collagen, a bone resorption marker, and decreased levels of N-propeptide (P1NP) of type 1 procollagen, a bone formation marker, according to a May 26 report in the Journal of the American Geriatrics Society, published online in the […]

Winter is here. With it, depressive symptoms worsen each year. Sadly, suicide continues to claim more lives than firearms in the United States, and suicide rates are increasing in nearly every state. The Centers for Disease Control and Prevention reports that deaths by suicide have increased 30% since 1999, and similar trends are seen in […]

Older adults with chronic low back pain and depression will participate in the final year of a five-year study designed to determine whether medication alone or medication combined with health coaching and learning new problem-solving skills is the best treatment for both conditions.The ADAPT (Addressing Depression and Pain Together) study is an initiative led by […]

Functional magnetic resonance imaging of the brain may help predict which patients will respond favorably to antidepressant treatment, according to a study published in the journal Brain. Researchers from the University of Illinois at Chicago and the University of Michigan conducted fMRI scans of patients with major depressive disorder who were about to begin antidepressant […]

Since its approval in 1995, the opioid tramadol (sold under the names Conzip and Ultram) has become widely prescribed for the treatment of osteoarthritis and other painful conditions, in part because of its lower risk of some side effects and lower potential for abuse than other opioids. It has become a popular drug. It is […]

Clinician-scientists from Inserm, CNRS, the Sorbonne, AP-HP, and the Institut de Recherche en Brain de Paris have identified one mechanism that explains ketamine’s effect as an antidepressant. Ketamine, normally used as an anesthetic, was administered to patients with severe resistant depression. The treatment increased patients’ ability to overcome negative beliefs about themselves and the world […]

The American College of Physicians (ACP) has published updated guidelines outlining clinical recommendations for nonpharmacologic and pharmacologic treatment of adults in the acute phase of major depressive disorder (MDD). In the updated clinical guidelines, ACP recommends the use of cognitive behavioral therapy (CBT) or second-generation antidepressants (SSRIs) as initial treatment for adults with moderate to […]

A new study by researchers from the University of Limerick and the University of Iowa in Ireland has found that resistance training has an impact on the treatment of anxiety and depressive symptoms. The new study provides evidence that resistance training has an effect on anxiety and depression and looks at the possible mechanisms behind […]

Most stroke survivors could safely take two common antidepressants, according to a preliminary study to be presented at the American Stroke Association’s International Stroke Conference 2024. The conference will be held February 7-9 in Phoenix. Among ischemic (blood clot-causing) stroke patients who were started on antidepressants known as SSRIs (selective serotonin reuptake inhibitors) and/or SNRIs […]

Researchers at Stanford Medical School conducted a study in which they described a new category of depression called the cognitive biotype, which accounts for 27% of depressed patients and is not effectively treated with commonly prescribed antidepressants. Cognitive tasks have shown that these patients have difficulty with the ability to plan for the future, exercise […]